Epithelioid Hemangioendothelioma of the Liver

This is a case report of 52-year-old healthy male who was found two liver nodules in the right lobe during routine checkup. The physical examinations and laboratory investigations were unremanable. Core biopsy of the liver was done and the diagnosis of metastatic adenocarcinoma was suggested without a definite primary lesion. Since cholangiocarcinoma was suspected, subsegmently, partial hepatectomy and segmentectomy, segment 4, 6, and 7, was performed. Additional intraoperative findings were two peritoneal nodules in one kidney and duodenum. The hepatoduodenal and common hepatic lymph nodes were also enlarged. Gross examination revealed light brown nodular lesions ranging from 2 to 2.3 cm in the right lobe and a gray white nodule, 0.6 cm in the greatest dimension, in the segment 4 of the liver. Histologic examination displayed expanding tumors comprised of epithelioid neoplastic cells in fibromyxoid stroma which may be difficult to distinguish from other carcinoma such as, cholangiocarcinoma, metastatic adenocarcinoma, and undifferentiated